我目前的研究领域可以称为人类数量遗传学(quantitative genetics。我们的研究往往需要大样本数据做支撑,成千、上万、甚至更多的参与者。目前该领域,大部分的可获得数据是欧洲人种的数据。
所以,我写这个博客,关注一下目前我知道的收集中国人数据的队列研究(cohort study)。需要注意,中国有法律管控相关的队列研究,并且之前发生过争议事件。
ChinaMap with 10k individuals: paper
WeGene with 0.1m individuals: paper
China Kadoorie Biobank with 0.5m individuals: paper, paper2, website
Taizhou longitudinal study with 0.2m individuals: news
Chinese National Twin Registry with 61k twin pairs: paper
Westlake BioBank for Chinese (WBBC): paper1, paper2, website
中国队列共享平台
Guangxi, China: the Fangchenggang Area Male Health and Examination Survey (FAMHES) with 4,303 men paper1
4D-SZ
gut microbiome and blood metabolites from BGI-Shenzhen, “3,432 Chinese individuals with whole-genome, whole-metagenome, anthropometric and blood metabolic trait data” - Liu et al. Nature Genetics 2022
COVID gwas from Wang Chaolong group at Wuhan, “genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of Chinese ancestry” - Wu et al. Communications biology, 2021
fingerprint gwas from Jin Li group at Fudan/Shanghai, “9,909 individuals from three Han Chinese cohorts” - Li et al. Cell, 2022
NyuWa Chinese Population Variant Database (NCVD): paper, website
Chinese Millionome Database: paper, website
Born in Guangzhou Cohort Study (BIGCS)
评论文章:
zhishifenzi: 中国百万人群大队列,何去何从?
饶议科学:
公开和共享中国人基因序列的好处
外国人要利用中国病人的样本资源吗?
<中国人泛基因组图谱上Nature引争议,基因数据究竟该不该共享?>